Mind & Mood

Does a lack of purpose signal cognitive change?

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By , Executive Editor, Harvard Health Letter
  • Reviewed by Anthony L. Komaroff, MD, Editor in Chief, Harvard Health Letter; Editorial Advisory Board Member, Harvard Health Publishing

A stack of wood blocks with blue labels on the front that read what is my life purpose?

A study published online Aug. 13, 2024, by the Journal of Neurology, Neurosurgery and Psychiatry suggests that a lack of purpose in life and a lack of personal growth might be early signs of cognitive decline. The study involved more than 900 dementia-free people (average age 79 at the start of the study) who were followed for up to 14 years. Once a year, participants took cognitive tests, had neurological exams, and underwent assessments measuring aspects of well-being. Compared with people whose thinking skills remained sharp, those who developed mild cognitive impairment (MCI) — a precursor to dementia — had lower levels of purpose three years before an MCI diagnosis, and lower levels of personal growth six years before an MCI diagnosis. The study is observational and can't distinguish cause from effect: does developing dementia interfere with purpose and personal growth, or do these deficiencies contribute to the development of dementia? However, we know from other evidence that having a sense of purpose is linked to sharp memory and thinking skills, as well as mood control, reduced risks of chronic disease, and longevity.

Image: © Frederica Aban/Getty Images

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About the Author

photo of Heidi Godman

Heidi Godman, Executive Editor, Harvard Health Letter

Heidi Godman is the executive editor of the Harvard Health Letter. Before coming to the Health Letter, she was an award-winning television news anchor and medical reporter for 25 years. Heidi was named a journalism fellow … See Full Bio
View all posts by Heidi Godman

About the Reviewer

photo of Anthony L. Komaroff, MD

Anthony L. Komaroff, MD, Editor in Chief, Harvard Health Letter; Editorial Advisory Board Member, Harvard Health Publishing

Dr. Anthony L. Komaroff is the Steven P. SimcoxPatrick A. Clifford/James H. Higby Distinguished Professor of Medicine at Harvard Medical School, senior physician at Brigham and Women’s Hospital in Boston, and editor in chief of the … See Full Bio
View all posts by Anthony L. Komaroff, MD

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