Mind & Mood
Major depression more likely during perimenopause than during premenopause
A history of major depression, psychiatric drug use, high body mass index, and upsetting life events were all independent risk factors for major depression, but none of them could explain why it peaked during perimenopause and early postmenopause. Depression did not correlate with hot flashes or changes in reproductive hormones, which are specifically associated with perimenopause.
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