On call: No-flush niacin
On call
To have benefit, though, niacin has to be absorbed into the bloodstream. Nicotinic acid is well absorbed. "Immediate-release," "crystalline," and "plain" forms of niacin are rapidly absorbed forms of nicotinic acid; in the proper dose, they can improve all three blood lipids, but they also cause flushing and itching. Sustained-release forms of niacin also deliver nicotinic acid to the bloodstream; they cause less flushing, but some preparations have been linked to a significant risk of liver inflammation and other side effects. Intermediate-release niacin delivers effective amounts of nicotinic acid with a modest risk of flushing and a good safety record. Most experts favor intermediate-release niacin.
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