Alzheimer's Disease Archive

These strategies may offer greater protection.

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While there's no cure for Alzheimer's disease, ongoing research has suggested there may be ways to lower your risk.

"Much of the existing science supports how certain behavioral changes made in middle age can protect people as they grow older," says Dr. Kirk Daffner, director for the Center for Brain/Mind Medicine at Harvard-affiliated Brigham and Women's Hospital. "However, there is evidence that adopting certain healthy lifestyle habits can benefit older adults too."

One of the most dangerous and distressing symptoms of Alzheimer's is wandering. It may seem unfathomable that a person might suddenly get up at night to go to the post office or leave home at any hour for no apparent reason. But wandering may be prompted by deep-seated memories of work, chores, or hobbies, or a longing to return to a former home.

The inability to control wandering is what often drives families to decide to place a loved one in a nursing home. However, there are some simple measures to prevent wandering that often work well for a time and can even help postpone that difficult decision.

In the journals

So far, research has been mixed on whether brain training programs can improve or slow memory decline. Yet a new study published online Jan. 4, 2018, by the Journal of the American Geriatrics Society found that brain training may help people with mild cognitive impairment (MCI), the stage between normal brain aging and dementia.

Researchers recruited 145 adults, average age 72, who were diagnosed with MCI. They were split into three groups. Those in one group did two hours of brain training every week for two months. The training focused on improving memory by learning new strategies to better encode information. For example, they remembered errands by associating tasks with specific locations in their home, a process called method of loci. They also practiced how to better control their attention.

Research we're watching

Drinking too much alcohol could raise the risk of developing early-onset dementia, says a study published online Feb. 20, 2018, by The Lancet Public Health.

In the journals

Older adults who develop hearing loss are more likely to experience greater cognitive decline and develop dementia than their counterparts without hearing problems, according to a meta-analysis published online Dec. 7, 2017, by JAMA Otolaryngology — Head and Neck Surgery. Researchers examined data from 36 studies including more than 20,000 people who underwent both cognitive evaluations and hearing tests. Those with age-related hearing loss were more likely to have cognitive impairment or a diagnosis of dementia.

The study found a small but statistically meaningful association between hearing loss and a variety of specific cognitive abilities, including executive function, memory, processing speed, and visuospatial ability (how you recognize shapes and sizes and estimate the distance between two objects). The association between hearing loss and weaker cognitive skills was still strong even after accounting for risk factors like high blood pressure and smoking.

If you are noticing problems in yourself or a loved one, here's where to turn for help and support.

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You're talking with a friend about a movie you saw recently, but can't remember the actor's name. Last week you found yourself upstairs, but couldn't remember what you came up to look for. Your keys are always missing. You worry: are these normal memory lapses or early signs of Alzheimer's disease or another form of dementia?

"Because there has been so much attention paid lately to the aging baby boomer population, I think Alzheimer's disease is getting a lot of attention, which is leading a lot of people to believe they may have the condition," says Dr. Suzanne Salamon, associate chief of the gerontology division at Beth Israel Deaconess Medical Center and assistant professor of medicine at Harvard Medical School.

News briefs

You've probably heard about tests to measure chemicals in the blood that indicate chronic inflammation in the body. They are sometimes used to estimate risk for heart disease. But what about using these kinds of biomarkers to gauge your risk for declining brain health? A study published Nov. 1, 2017, in Neurology found that having certain inflammatory markers in midlife was associated with brain shrinkage and poor memory in older age.

Researchers measured five inflammation biomarkers in about 1,600 middle-aged people and gave them brain scans and a memory test about 25 years later. Compared with people with no elevated inflammation markers, people with high levels of three or more biomarkers scored lower on the memory test and had about 5% shrinkage in the hippocampus and other parts of the brain associated with Alzheimer's disease.

Research we're watching

Among people who have atrial fibrillation (afib), those who take anti-clotting medications may be less likely to develop dementia later in life than those who don't take the drugs, a new study finds.

Afib, a disorder marked by a rapid, irregular heartbeat, raises the risk of stroke as well as dementia. Anti-clotting drugs are known to lower the risk of stroke, but the drugs' effects on dementia weren't clear. So Swedish researchers examined hospital and pharmacy registry data from nearly half a million people who were diagnosed with afib between 2006 and 2014.

In the journals

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If you have persistent trouble detecting or identifying odors, that may be an early sign of dementia, according to a study in the Sept. 25, 2017, Journal of the American Geriatrics Society. Almost 3,000 older adults, ages 57 to 85, who did not have dementia were asked to detect and identify five common odors like peppermint, fish, orange, rose, and leather. Five years later, the researchers found that almost half of those who performed poorly on the smell test (were either unable to detect the odors or unable to identify what the smells were) had been diagnosed with dementia. In comparison, 79% of those who scored high on the smell test did not have dementia.

The results only show an association between poor sense of smell and dementia, but the researchers noted that a smell test could be a simple way to identify high-risk people. It isn't clear how sense of smell and dementia may be linked, but the researchers speculated that underlying causes of dementia, like amyloid plaque buildup and tau tangles in the brain, also may affect the olfactory (sense of smell) system.

MCI can be tough to identify, but there may be ways to postpone, and possibly prevent, its impact on memory and thinking.

Everyone has the occasional bout of forgetfulness, whether it's misplacing your keys or blanking out on a name. But if these episodes become frequent or interfere with daily life, you may have mild cognitive impairment, or MCI.

MCI falls somewhere between the usual cognitive decline of normal aging and the more serious signs of dementia and Alzheimer's disease. An estimated 10% to 20% of adults older than 65 have MCI, according to the Alzheimer's Association. But this gray area of brain health is often difficult to detect.