Cholesterol Archive

The two main side effects caused by statins are muscle aches (which disappear once the drug is stopped) and a higher risk of diabetes (which is most common in people with obesity and prediabetes).

About 5% of Americans have low-density lipoprotein (LDL) values of 190 mg/dL or higher. Their risk of heart disease is five times higher than people with near-optimal values (less than 130 mg/dL). Some have familial hypercholesterolemia, a genetic condition that can lead to LDL values up to 350 mg/dL (or even higher in some cases). Known as FH, it's a common cause of early heart attacks.

People who have stable angina despite taking medications can be treated with stents or bypass surgery. The best choice depends on the location and complexity of the artery blockages and other health conditions.

High levels of lipoprotein(a), or Lp(a)—a variant of LDL (bad) cholesterol— may triple the risk of a heart attack, even among healthy people with no other known risks for heart disease.

The scientific understanding of HDL cholesterol has evolved in recent years, and many cardiologists now believe that HDL may be more of a bystander rather than a "good guy" that helps lower heart disease risk. While some types of HDL are great at plucking excess cholesterol from LDL and artery walls (a process referred to as reverse cholesterol transport) other types of HDL don't do this. In clinical trials, medications to raise HDL levels—including a drug specifically designed to improve reverse cholesterol transport—have not succeeded in lowering heart attacks and strokes.

People can reduce their LDL cholesterol in three ways. One strategy involves dietary changes, such as eating more fiber-rich foods and swapping saturated fats for unsaturated fat. Another is to take one of several dietary supplements, including psyllium, plant sterols, or red yeast rice. The third entails taking a prescription medication, such as a statin. Many factors can affect whether these different strategies are advisable or useful, including a person's age and other risk factors for heart disease, their current dietary habits, and the quality of the supplements they take.

Studies have shown a link between lower risks of cardiovascular disease, some cancers, and even dementia in people who consume higher amounts of olive oil. However, no definitive studies show extra-virgin olive oil has greater benefits than regular olive oil.

Using a Web-based app, most people can correctly assess their need for a cholesterol-lowering statin and take the drug appropriately with good results, according to a 2024 study. If approved, the app could facilitate statin use without a doctor's prescription.

A 2024 study found that people with high blood sugar and high triglycerides are more likely to develop chronic stress, anxiety, or depression later in life, compared with people who have low or normal blood sugar levels.