Cholesterol Archive

For people older than 75 who have heart disease already, or who are at increased risk of developing heart disease, there now is solid evidence that statins remain effective at lowering cholesterol and, more important, in reducing the risk of new or recurrent heart disease. For people older than 75 who have not been diagnosed with heart disease and are not at increased risk for developing it, the value of statins still is uncertain.

The portfolio diet, which emphasizes foods rich in fiber and healthy fats, helps lower LDL cholesterol. A 2023 study suggests that the more closely people follow the diet, the lower their risk of cardiovascular disease. The diet discourages foods from animal sources and features foods from five main categories, including (1) plant protein such as legumes; (2) nuts and seeds; (3) foods rich in viscous fibers such as oatmeal, eggplant, and berries; (4) plant sterols such as phytosterol-enriched margarine; and (5) monounsaturated fats such as olive and canola oils.

Skin tags are fleshy, soft growths that tend to develop on the neck, under the arms, or around the groin. People who develop many skin tags should see their doctor, since they may be associated with diabetes or metabolic syndrome. Skin tags can be removed using various methods.

People who get most of their recommended weekly physical activity over one or two days may lower their heart disease risk just as much as those who are active more regularly throughout the week. Evidence also suggests there's no particular benefit to exercising at certain times of the day, including with respect to mealtimes. So people should be physically active whenever they find it to be most convenient.

Too much saturated fat tends to raise levels of harmful LDL cholesterol, but limited amounts are not a problem. Eating mostly whole or minimally processed foods can help achieve that goal.

For people who have risk factors for heart disease, it's important to make lifestyle changes like losing weight, getting more exercise, and eating a healthier diet. Longstanding habits are hard to change, but managing the challenge of healthy eating is easier if people have a partner who is supportive and involved in making food choices.

A 2023 study suggests taking testosterone replacement therapy does not raise the risk for heart attacks or stroke among men with cardiovascular disease or a high risk for it, but it could increase the risk of atrial fibrillation, acute kidney injury, and pulmonary embolism.

The cholesterol-lowering drug bempedoic acid (Nexletol) can be a good alternative for people who can't take statins. A 2023 study found that compared with a placebo, bempedoic acid can lower the risk of heart attacks and related problems.