Diabetes Archive

Prediabetes often precedes the development of type 2 diabetes, and in young and middle-aged people it's important to identify prediabetes because it may be possible to prevent or delay the development of diabetes. Researchers wanted to know if the implications of being diagnosed with prediabetes are similar for older adults.

In the journals

Can you be "fat and fit" — that is, overweight but still healthy because of regular exercise? There is no simple answer. But one study says that activity does not entirely reverse the effects weight has on heart health. The findings were published online Jan. 26, 2021, by the European Journal of Preventive Cardiology.

The study involved more than 527,000 adults, almost 70% of whom were men. People were placed into three groups based on their body mass index (BMI): normal, overweight, and obese. They also were grouped by activity level: regularly active (the minimum requirement from the World Health Organization, or WHO); insufficiently active (less than the WHO minimum, but some moderate to vigorous physical activity every week), and no exercise.

While eye problems can affect people of any age, some conditions become more common after age 40. Some are normal, or at least expected; others are of greater concern and will require treatment. Here’s how to keep your eyes healthy and address certain problems.

News briefs

Ever wonder how much exercise time it takes to start reducing your risk for heart disease and diabetes? It could be as little as 12 minutes, according to a Harvard study published Nov. 17, 2020, in Circulation. Scientists analyzed blood from more than 400 middle-aged men and women before and just after they'd pedaled for 12 minutes on cycling machines, reaching a vigorous rate. In particular, scientists measured levels of almost 600 natural body chemicals (metabolites). Exercise produced significant changes in most metabolites. For example, the level of one metabolite linked to heart disease and diabetes fell by 29%. Another metabolite tied to diabetes risk and liver disease fell by 18%. That suggests, but doesn't prove, that 12 minutes of daily exercise (that includes vigorous activity) might reduce the risk of heart disease and diabetes. What if you're more of a moderate-intensity exerciser? "We don't know yet if moderate-intensity exercise would have a similar effect on metabolites. But study participants started off with very light exercise, and each minute the intensity increased," says Dr. Gregory Lewis, the study's senior author and a cardiologist at Harvard-affiliated Massachusetts General Hospital.

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News briefs

A Mediterranean-style diet is rich in vegetables, legumes, fruits, whole grains, nuts, seeds, poultry, fish, and olive oil, and it's associated with lower risks for heart disease and diabetes. And a "greener" version of the eating style might be even more effective, according to a small, randomized study published online Nov. 23, 2020, by the journal Heart. Researchers — some from Harvard — recruited about 300 sedentary, middle-aged people (mostly men) with high cholesterol or abdominal obesity and divided them into three groups. One received guidance for exercise and a healthy diet; another received exercise guidance and was assigned to eat a calorie-restricted Mediterranean diet; and one group received exercise guidance and was assigned to eat a "greener" calorie-restricted Mediterranean diet with less animal-based and more plant-based proteins (including walnuts and a type of duckweed — an aquatic plant), plus lots of green tea. After six months, people on the "green" diet had lost more weight and inches around their middles, and had bigger drops in cholesterol, than people in the other two groups. "Green" dieters also had steeper declines in insulin resistance, inflammation markers, and diastolic blood pressure (the lower number in the measurement), compared with the other two groups.

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Research we're watching

A unique diabetes drug shows heart-related benefits in people with diabetes who also have recently worsening heart failure or kidney disease, according to two new studies.

The drug, sotagliflozin (Zynquista), belongs to a class of drugs called SGLT2 inhibitors, which cause the kidneys to release more sugar into the urine. The drug is also an SGLT1 inhibitor, meaning it decreases sugar absorption in the intestines. This dual action lowers high blood sugar, the hallmark of diabetes. In people with kidney disease, sotagliflozin lowered the total number of deaths from cardiovascular disease and hospitalizations and urgent visits for heart failure by about 26% compared with a placebo. In a second study, which included people with recently worsening heart failure, those taking the drug had a 33% decrease in those same heart-related measures compared with a placebo.

Research we're watching

Doing vigorous exercise for just 12 minutes triggers changes in blood levels of substances linked to cardiovascular health, new research finds.

The study used data from 411 middle-aged adults from the Framingham Heart Study. Researchers measured levels of 588 substances involved in metabolism (metabolites) in the volunteers' blood before and immediately after 12 minutes of vigorous exercise on an exercise bike.