Diseases & Conditions Archive

In gastroesophageal reflux disease (GERD), stomach acid washes backward into the esophagus. This can cause symptoms such as heartburn, an acidic or metallic taste in the mouth, hoarse voice, chest pain, dry cough, post-nasal drip, or trouble swallowing. Symptoms can overlap with those of several other conditions. These include hiatal hernia, functional dyspepsia, eosinophilic esophagitis, esophageal spasms, or heart attack. Distinguishing GERD from other conditions may involve various tests, including an endoscopy to view the esophagus lining.

Burning mouth syndrome affects about 2% of people, with women up to seven times more likely than men to be diagnosed. Symptoms include burning sensations in the lips, mouth, or throat as well as stabbing pain, tingling, a sour or metallic taste, or the sense that something is crawling inside the mouth. Women's hormone dips during perimenopause and beyond may play a role in the condition, and stress and anxiety are also considered risk factors. To confirm the diagnosis, doctors must first rule out other potential causes of symptoms.

A 2025 randomized controlled trial found that GLP-1 receptor agonists, the blockbuster drugs approved to treat diabetes and obesity, boosted the walking ability of people with diabetes and peripheral artery disease (PAD) in the legs. The news is encouraging, since there are few effective treatments for PAD-reduced blood flow in the limbs that leads to pain with activity. However, it will take more evidence before doctors feel comfortable prescribing GLP-1s if a person only has PAD.