Genes Archive

A one-time infusion of a gene-editing therapy called CTX310 may safely lower cholesterol and triglyceride levels, according to a small preliminary trial. The first-in-human study, published in 2025, included 15 people with uncontrolled LDL cholesterol, triglycerides, or both.

Long QT syndrome is a disorder of the heart’s electrical system that can be either acquired (for example, due to a medication) or congenital. Although usually people have no symptoms, it can cause a fast, erratic heartbeat that may lead to shortness of breath, fainting, and sometimes death.

Metabolism—how your body turns food into energy—is strongly influenced by genes, but lifestyle still matters. Choosing nourishing foods, avoiding extreme diets, and building muscle through regular exercise can modestly boost calorie burning and support weight loss.

A 2025 study of over 5,600 women and men followed for over 30 years found that following a Mediterranean diet may reduce the risk of Alzheimer’s disease and improve cognitive function. The effect is strongest in people who carry two copies of the Alzheimer’s risk gene APOE4.

An inexpensive blood test that checks for a genetic variant of Lp(a)—a fatty particle similar to LDL cholesterol—may help clarify who might benefit from a daily low-dose aspirin, according to a 2025 review of study findings.

Direct-to-consumer genetic tests can screen for rare heart conditions that arise from variants in a single gene (such as cardiomyopathies) as well as common conditions influenced by many thousands of gene variants (such as coronary artery disease). But because the results are not definitive, they can be challenging to interpret.