Heart Health Archive

Research we're watching

Infections — especially those in the urinary tract, known as UTIs — may raise the risk of a stroke, a new study finds.

Researchers examined the electronic medical records of more than 191,000 stroke patients to see if they'd been hospitalized or gone to an emergency room for an infection shortly before the stroke. They tracked infections of the abdomen, blood, respiratory tract, skin, or urinary tract.

In the journals

Eating large amounts of red meat can raise LDL (bad) cholesterol levels, but new research suggests you should curb your intake of white meat, too. The findings were published online June 4, 2019, by The American Journal of Clinical Nutrition.

Researchers randomly assigned 113 healthy adults, ages 21 to 65, to follow a four-week diet with high levels of either red meat, white meat (chicken and turkey), or plant-based protein (such as nuts, whole grains, soy products, and legumes). Afterward, LDL levels in the high-red-meat diet group rose, as predicted, but the researchers found that high levels of poultry had the same effect on LDL levels as red meat.

A substance called trimethylamine N-oxide, which is produced when your body digests red meat, may raise the risk of cardiovascular problems.

Experts used to think that red meat raised your risk of heart disease simply because it was high in saturated fat. But today that picture has gotten more complicated thanks to the discovery of a metabolite — a substance produced during digestion and metabolism — called trimethylamine N-oxide, or TMAO.

According to a news article published June 11 in JAMA, three recent analyses have linked high blood levels of TMAO with a higher risk for both cardiovascular disease and early death from any cause. In one of those studies, researchers found that people with higher levels of TMAO in their blood may have more than twice the risk of heart attack, stroke, or other serious cardiovascular problems, compared with people who have lower levels. Other studies have found links between high TMAO levels and heart failure and chronic kidney disease.

Research we're watching

If you have coronary artery disease, you may be at higher risk for cognitive problems, according to a study published in the June issue of the Journal of the American College of Cardiology. People with coronary artery disease have blockages in the arteries that lead to the heart. When blood flow to the heart is slowed or blocked, the result can be a heart attack or the chest pain known as angina.

Study authors looked to see whether this condition had any effect on thinking skills. They selected people with no history of heart disease and followed them for 12 years, administering three cognitive tests throughout the course of the study. Ultimately, 5.6% of people in the study experienced a heart attack or angina. Researchers found that these people were not more likely to have experienced cognitive decline before their heart episode or immediately after, but were at much higher risk for cognitive decline in the years that followed. It's not clear why this occurred, but the study authors say that doctors should be aware of this risk and should monitor people with coronary artery disease carefully.

It's your doctor's call, but it's good to understand, and to weigh, your options.

Your heart doesn't just pump blood—it needs blood to survive. So, when blocked coronary arteries threaten the heart's blood supply, something must be done.

Ask the doctor

Q. My cardiologist mentioned that he was going to do a "bubble study" during my echocardiogram. What is that?

A. During an echocardiogram, a technician uses a probe that emits high-frequency sound waves (ultrasound) that "echo" off the structures of your heart. The waves, which are translated into video images visible on a monitor, can reveal in-formation about your heart's structure and function. A bubble study gives added information, as it can identify potential blood flow issues inside your heart.

Plenty of people avoid red meat or eat only small amounts of it. But relying on white meat for protein may not be such a good nutrition choice either. According to the results of a small study, those who ate red meat and white meat had similarly higher cholesterol levels.

There are several things you can do to prevent or minimize the aches and pains that might accompany statin use.

If you're not taking a statin now, you may well be soon. These medications are commonly prescribed to lower "bad" LDL cholesterol and have been shown to reduce the risk of heart attack, stroke, and death. They are routinely recommended for people who have cardiovascular disease and for many people ages 40 to 75 who don't have cardiovascular disease but have at least one risk factor (high blood pressure, high cholesterol, diabetes, or smoking) and a 7.5% or greater risk of a stroke or heart attack in the next decade. Moreover, recent research indicates that they may benefit high risk individuals over age 75 as well.

Muscle pain and other statin side effects

Taking a statin may give you some assurance that you're doing all you can to avoid heart attack and stroke, but you may also experience side effects. Reported side effects include an increased chance of developing diabetes — which is largely restricted to people who are already at risk for diabetes, and who can be monitored with glucose or hemoglobin A1c tests. Statin use has also been associated with difficulties with memory and reasoning, although there is no clear evidence that the drugs were responsible. In very rare cases, statins may cause liver problems or a potentially life-threatening breakdown in muscle cells.

Research we're watching

Got a high cholesterol reading? You may have a higher risk for a dangerous eye condition called glaucoma, according to a recent study published online May 2 by JAMA Ophthalmology. The condition, characterized by pressure in the eye that can damage the optic nerve, can lead to vision loss.

The study looked at 866 cases of primary open-angle glaucoma, the most common type of glaucoma, among more than 136,000 study participants who were followed for 15 or more years. Participants provided researchers with updates on statin use and cholesterol levels every other year throughout the study period. After analyzing the information, study authors found that for every 20-point increase in total cholesterol there was a 7% increase in glaucoma risk. But the use of cholesterol-lowering statin drugs seemed to reduce risk. People who used statins for five years or longer had a 21% lower risk of developing glaucoma.

News briefs

Vitamins and supplements won't help stave off dementia, but a healthy lifestyle might, suggest new guidelines released May 19, 2019, by the World Health Organization (WHO). The WHO warns that the number of new dementia cases around the world — currently 10 million per year — is set to triple by 2050. While there's no cure for any kind of dementia (such as Alzheimer's disease and vascular dementia), the WHO says it may be possible to delay the onset of the disease or slow its progression. The key: managing modifiable risks, such as chronic disease and unhealthy habits. The guidelines recommend that you keep your weight, cholesterol, blood pressure, and blood sugar under control; get lots of exercise; and eat a Mediterranean-style diet (which emphasizes olive oil, fruits, vegetables, nuts, and fish; minimizes red meats and processed meats; and includes a moderate amount of cheese and wine). The WHO also advises that you don't smoke and you avoid harmful use of alcohol (no more than one drink per day for women, no more than two drinks for men). But don't count on supplements to help you stave off dementia. The WHO says there's no evidence that vitamin B, vitamin E, multivitamins, or fish oil supplements help reduce the risk for dementia. The agency recommends against using supplements as a means to ward off cognitive decline.

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