Medications Archive

When doctors say that it's okay to take proton-pump inhibitors (PPIs) "on demand" for chronic heartburn, the advice doesn't apply to everyone. PPIs inhibit the production of stomach acid, which can back up into the esophagus and can cause pain (heartburn) and damage the lining of the esophagus. People with damage to the esophagus often stay on PPIs long-term to prevent further problems. People without damage to the esophagus can take a short course of PPIs as needed.

Psychedelic drugs such as psilocybin (found in "magic mushrooms") and 5-MeO-DMT (a compound derived from toad venom) are being tested for treating cases of depression that don't respond to standard treatments. New depression approaches are needed since current treatments don't work in nearly half of patients. Hallucinogenics may change longstanding thought patterns or promote new connections in brain neurons. Benefits of psilocybin on mood appear to be long-lasting. FDA approval for psilocybin will likely take several more years.

Acetaminophen (Tylenol) is often recommended for pain relief in people with high blood pressure because most other options can raise blood pressure. A 2022 study suggests acetaminophen might sometimes have a similar effect.

Nighttime skin itching can stem from dry skin, hormone changes, certain medications and skin care products, and rarely, a more serious illness. It can help to change bedding or pajamas, take short baths or showers, apply moisturizer liberally, and use a humidifier.

People who have been taking antidepressants for some time may wish to stop taking them due to unpleasant side effects. This can be accomplished, but it is best to taper the dosage slowly and be aware of the potential for discontinuation symptoms.

Osteoarthritis in the hand is a painful condition that is more common in women than in men. While this condition can be debilitating, a number of strategies can be used to manage it, including using various topical, oral, and injected pain medications; splinting the joint; making lifestyle changes; and working with a hand therapist. Surgery may be an option when other measures have failed to control symptoms.

The medical world agrees that daily aspirin can help people with cardiovascular disease lower their risk of heart attacks and strokes. However, most people over age 70 without cardiovascular disease should avoid aspirin as a way to prevent a heart attack or stroke. Even if a person has taken aspirin for a long time as primary prevention of heart disease, it's time to talk to your doctor about potentially stopping it.

A placebo response (improvement in symptoms from the act of taking a drug independent of its biological effects) is not fully understood. Still, placebos are commonly used in clinical trials to test the effectiveness of a specific therapy.

A study published online Feb. 16, 2022, by the European Heart Journal suggests that the prevalence of statin intolerance is much lower than commonly cited. Instead of 50%, the study found that prevalence is 6% to 10%.