Medications Archive

Articles

Blood pressure medications may affect your mood

Contrary to conventional wisdom, some blood pressure drugs are linked to a lower risk of depression.

Like all medications, blood pressure drugs sometimes cause unwanted side effects. While many are mild and short-lived, some are more worrisome, including mood changes such as depression. But contrary to what doctors have long assumed, blood pressure drugs may not raise the risk of depression. In fact, some appear to be linked to a lower risk, according to a recent study (see "Depression rates in people taking different blood pressure drugs").

"The traditional view has been that blood pressure drugs that cross the blood-brain barrier are more likely to cause depression," says Dr. Randall -Zusman, a cardiologist at Harvard-affiliated Massachusetts General Hospital. Depression has also been associated with drugs known as beta blockers. But beta blockers (which work in part by slowing the heart rate) can also make you feel tired and listless, which may dampen your mood, Dr. Zusman explains.

Why do my legs swell at the end of the day?

On call

Q. I would occasionally get some swelling in my legs. But now I notice it by late afternoon every day. I otherwise feel fine. Should I be worried?

A. It sounds like you have edema, swelling in your legs due to fluid in the soft tissues beneath your skin. This usually occurs when pressure from the fluid inside your veins is high, which forces water out of the blood vessels and into the surrounding tissues.

Fish oil drug helps shrink plaque in heart arteries

Research we're watching

A drug made from a highly purified form of EPA (an omega-3 fatty acid found in fish) appears to help reduce plaque in the heart's arteries, according to a study published online Aug. 29, 2020, by the European Heart Journal. The findings may explain why the drug, icosapent ethyl (Vascepa), lowers the risk of heart attack and stroke by 26% in people at high risk for those serious problems.

The study included 80 people with fatty plaque in the arteries of the heart (coronary artery disease). Most of them had diabetes and were taking a statin. Their trigly­cerides were elevated, ranging from 135 to 499 milligrams per deciliter. Half were randomly assigned to take 4 grams of icosapent ethyl daily; the other half received a placebo.

Unlocking the mystery of chronic pelvic pain syndrome

The condition is an all-too-real problem for men, and one of the more difficult to treat.

After age 50, men often have periods of discomfort "down there." It could be a cramping, aching, or throbbing pain in and around your pelvis and genitals. You also may have issues in the bedroom and bathroom. While the problems are real, the cause is often difficult to pinpoint.

It's called chronic pelvic pain syndrome (CPPS) — also known as chronic prostatitis — and it's one of the most puzzling and difficult-to-manage conditions for older men.

Is there a cure for my nightly snoring?

Ask the doctors

Q. My partner says I've been snoring lately. Are there any home remedies I can use to help me stop?

A. Snoring occurs when muscles in your airway relax during sleep, narrowing the airway and making your breath sounds louder as the air forces its way through. There are a number of strategies that can help. Try sleeping on your side instead of your back, which pushes your tongue to the back of your mouth. Clear nasal congestion resulting from allergies or a stuffy nose. Avoid alcohol (which may act as a sedative) and sleep medications known as benzodiazepines, which may cause your airway tissues to relax, making snoring worse. Losing weight can also help, because surplus tissue, caused by weight gain, can put pressure on and compress the airway, making snoring worse. However, if your snoring does not improve, your partner notices that you have periods during the night where your breathing ­appears to stop, or you regularly feel drowsy during the day, it may be time to pay a visit to your doctor. You could have a condition called obstructive sleep apnea, which may require treatment.

Heart-related complications in people hospitalized with the flu

Research we're watching

Serious heart complications are common in people hospitalized with influenza, according to a study published online Aug. 25, 2020, by Annals of Internal Medicine.

Researchers from the CDC looked at the rates of cardiovascular problems in more than 80,000 adults hospitalized with a confirmed case of influenza (commonly called the flu) from 2010 to 2018. Almost 12% had a serious cardiovascular problem, most commonly heart failure or a lack of adequate blood flow to the heart, known as acute coronary syndrome. The body's immune response against the infection can trigger inflammation and other changes that harm the cardiovascular system.

What could cause low blood pressure?

On call

Q. My blood pressure stays low. Sometimes it drops so low, it causes dizziness and weakness. What causes this?

A. Of the possible causes of low blood pressure, two are at the top of my list. First, I would review your medications. Drugs prescribed to treat high blood pressure and heart disease are the ones that most often cause this side effect. Reducing the dose with your doctor's approval may be all you need.

Should I worry about a sudden swollen tongue?

On call

Q. What would cause my tongue to suddenly swell? Could this be a possible side effect of medication, or something else?

A. There are many reasons for a swollen tongue. Indeed, a reaction to a medication is one of the more common causes. For example, a well-known side effect of ACE inhibitors (a class of drugs used to control blood pressure) is a condition called angioneurotic edema. Swelling of the face, lips, and tongue can happen quickly in people who take an ACE inhibitor. The reaction may occur soon after it's first taken or at any time thereafter. Sometimes people get this reaction even though they have used the drug for several years. ACE inhibitors are more likely to cause angioneurotic edema in African Americans.

The new-old way to treat gout

New guidelines suggest doing more of the same. The problem is that many people don't.

You never forget your first gout attack. The severe pain, swelling, and redness hits hard and fast. The initial attack often strikes your big toe's large joint, but later ones might affect the foot or ankle. Other hot spots include the knees, hands, and wrists.

First-line treatment is quite effective and includes anti-inflammatory medications, ice therapy, and rest. A combination of diet and lifestyle changes and prescription drugs — an approach called urate-lowering therapy, or ULT — is typically recommended if attacks recur or become more severe.

Are you taking too many medications?

Peer into your pillbox: It may be time to streamline your drug regimen.

Medication regimens often start simply, perhaps with a multivitamin and a single prescription drug to treat a chronic condition. But with age and more health problems, a regimen may grow to include additional prescription drugs and dietary supplements (such as vitamin D and calcium), plus over-the-counter medicines to reduce symptoms such as pain or heartburn. In time, you can find yourself facing a crowded pillbox and a complicated regimen.

"Among people age 62 to about 85, a third will take five medications per person. In the higher-risk population that I take care of, those people average 15 medications per person. And some of the dialysis patients take about 20 prescriptions," says Joanne Doyle Petrongolo, a pharmacist at Harvard-affiliated Massachusetts General Hospital.

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