Medications Archive

Research we're watching

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Anti-inflammatory medications may play a role in ovarian cancer risk. A study by researchers at the Harvard T.H. Chan School of Public Health found that taking low-dose aspirin regularly appears to reduce the risk of ovarian cancer by 23%. However, long-term heavy use of ibuprofen (Advil), naproxen (Aleve), and other nonsteroidal anti-inflammatory drugs (NSAIDs) seems to increase risk.

The study, published online October 4 by JAMA Oncology, looked at data on more than 200,000 women who participated in the Nurses' Health Study and Nurses' Health Study II. Among the group studied, 1,054 women went on to develop ovarian cancer. Researchers then looked at what type of medications the women took on a regular basis. They found that women who took at least 10 doses of NSAIDs a week for multiple years had an increased risk of ovarian cancer. Women who took low-dose aspirin regularly seemed to have a reduced risk — but the same was not true among women who took a standard-dose aspirin.

On call

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Q. I have lost some of my sense of taste. I take medicine for high blood pressure. Could that be the reason?

A. The ability to enjoy food's flavor requires both your sense of taste and your sense of smell, which are triggered by the stimulation of nerve endings in the mouth and nose. As we age, our senses of smell and taste diminish. We lose taste buds, and those that remain shrink; and our tongue and nose become less discerning.

Explore more effective alternatives to help you get a good night's rest.

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You've spent the past few nights staring at the ceiling, thinking about your grocery list, lining up your tasks for the next day, or obsessing about your problem du jour — but what you really want to be doing is sleeping soundly. You're in the pharmacy and notice an array of over-the-counter sleep aids, and you're tempted. Will taking one help you get that deep slumber you crave?

Before you reach for that bottle, you might want to reconsider.

But use is primarily a concern for people who take them over a long period or who have certain health risks.

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Numerous studies in recent years have raised concerns that common pain relievers known as nonsteroidal anti-inflammatory drugs (NSAIDs) increase the risk of cardiovascular problems, such as heart attack and stroke.

A study published September 4 in The BMJ seems to confirm the risks associated with NSAIDs and notes that one medication in particular — diclofenac (Voltaren) — is associated with even higher risks to cardiovascular health than others in the same category.

Research we're watching

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Taking a low-dose aspirin every day could bring more risks than health benefits to healthy older adults, according to three papers from a single study, published online September 16 by The New England Journal of Medicine. The study, which began in 2010, included more than 19,000 adults ages 65 and older in the United States and Australia, who were free of cardiovascular disease, dementia, or disability, and followed participants for 4.7 years on average. Researchers found that treatment with a daily low-dose aspirin did not prevent dementia or disability. And rates of cardiovascular events (such as heart attacks and stroke) were similar between participants who took low-dose aspirin therapy and the comparison group that did not. While health outcomes were largely the same, people in the aspirin group were more likely than those who were not taking daily aspirin to experience significant bleeding, both in the gastrointestinal tract and the brain — a known risk of aspirin therapy.

While low-dose aspirin does not appear to benefit healthy older adults, this does not apply to people with known cardiovascular disease. For them, aspirin therapy significantly decreases risk of heart attack and stroke.

Ask the doctor

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Q. Is there something stronger than aspirin I can take for peripheral artery disease in my legs?

A. People with peripheral artery disease (PAD) in the legs have blockages (plaques of atherosclerosis) in the arteries that impair the flow of blood. Based on large scientific studies involving over 5,000 people with PAD, authorities recommend taking a daily aspirin tablet. For people with PAD, smoking cessation, regular exercise, and often other medicines such as statins, can help prevent further plaque buildup and decrease symptoms.

You have many alternatives for treating and controlling pain.

The opioid epidemic continues to rise in America, and a 2017 report from the National Initiative for the Care of the Elderly suggests the crisis now affects more older adults.

A main reason for the growing addiction to pain medicine is the ease with which it is often prescribed, according to Dr. Robert Jamison, a professor of anesthesia and psychiatry with Harvard-affiliated Brigham and Women's Hospital.

Although many older men enjoy active sex lives, most don't share sex-related questions and concerns with their doctor.

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While you discuss many subjects with your doctor, like proper blood pressure and cholesterol levels, your sex life probably doesn't make the list — but it should.

"Even though you may have an aging body, you can still feel healthy, vigorous, and full of life, and your sex life should be part of that," says Dr. Sharon Bober, director of the Sexual Health Program at Harvard-affiliated Dana-Farber Cancer Institute.

There are ways to shorten flare-ups and, in some people, prevent them from recurring.

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Psoriasis is a big star on TV drug ads, but this autoimmune skin disease is something most people try to keep well hidden.

"Psoriasis is among the most common skin conditions, affecting about 2% of the U.S. population, and while the condition doesn't affect everyone the same way, the approach to treatment and prevention is often similar," says Dr. Gideon Smith, an assistant professor of dermatology at Harvard-affiliated Massachusetts General Hospital.

Healthy older adults ages 75 and older might not benefit from the drugs to protect against cardiovascular disease.

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Cardiovascular disease is the leading cause of death for people ages 75 and over. The cholesterol-lowering statin drugs can help protect against heart attack or stroke, both for people who have already had one and those who are at high risk for one of these events.

But what if you are in this older age bracket and have no history of cardiovascular problems? Do you really need one of these cholesterol-lowering drugs to protect yourself from future heart attacks and strokes?