Medications Archive

Splitting a pill into two equal halves is sometimes necessary when needing to adjust dosage, or as a means to save money buy purchasing higher-dose pills. However, splitting is not safe for all pills, so a person should always consult a pharmacist or doctor.

Medications such as aspirin, statins, ACE inhibitors, and beta blockers are prescribed to certain patients to lower the chance of a first or repeat heart attack. New research shows that they also may reduce the severity of attacks that do occur.

Some drugs go too far, dulling emotions across the spectrum. A dose adjustment or a switch to a different medication can help.

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When your doctor prescribes a medication for depression, the goal is to reduce painful feelings of sadness or hopelessness. The majority of people taking the most commonly prescribed antidepressants—selective serotonin reuptake inhibitors (SSRIs)—improve substantially. But sometimes, SSRIs go beyond improving mood and make a person feel too little emotion. "Some people feel like they've lost the richness of daily life," says Dr. Michael Craig Miller, assistant professor of psychiatry at Harvard Medical School.

Serotonin and SSRIs

What you should do

Millions of older adults aren’t taking their blood pressure drugs as directed. Ways to combat adherence problems include asking a doctor for less expensive drugs, understanding what a medication is for, and reporting side effects. 

Prescription drug prices are rising. Three strategies may help lower your pharmacy bill.

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If you're trying to avoid (or already have) heart disease, chances are you're taking several prescription medications. In fact, about a third of adults over age 62 take at least five prescription drugs, which can be a real budget buster for some people. And recent rises in drug prices, especially for new, brand-name medications, are enough to make anyone gulp.

"By working with your doctor and your pharmacist and spending some time shopping around, you may be able to lower your pharmacy bill," says John Fanikos, director of pharmacy at Harvard-affiliated Brigham and Women's Hospital. He suggests three main strategies:

The discovery of 44 gene sites associated with high blood pressure may provide leads for developing new drugs to treat this common condition. 

Herbal supplements are sometimes advertised to improve a man’s sex life by increasing blood flow to the penis, but many are not proven effective for treating ED and may cause serious side effects.

A break from a medication is beneficial only in certain cases.

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When you think of a holiday, your medicine cabinet probably doesn't come to mind. But for people who take medications long-term, a drug holiday—a break from a medication for days or even years—may be helpful, for some medicines. "For some people, it gives the body a chance to recover the systems that have been suppressed by the drug," says Dr. Michael Craig Miller, assistant professor of psychiatry at Harvard Medical School.

Why take a break?

Using warfarin effectively is challenging—perhaps even more so than doctors have realized.

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For more than 60 years, warfarin has been a mainstay for people with atrial fibrillation. Used properly, warfarin may prevent as many as 60% of strokes related to this common heart rhythm disorder each year. But warfarin is notoriously tricky to manage because blood levels have to be kept within a narrow range to avoid side effects such as unwanted bleeding.

As a result, warfarin users must get frequent blood tests (see "What is an INR?") when they start the drug to fine-tune their dose. Once their INR values are consistently in the right range, most people scale back to testing every month or so. But a recent study suggests that people who take warfarin need to stay extra vigilant over the long term.

About 66% of adults over age 70 still take antihypertensive medication even though they now have low pressures, says a study from the University of Kent in the United Kingdom. Researchers say this exposes adults to medication side effects like dizziness and falls.