Medications Archive

News Briefs

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A Harvard study published March 3, 2016, in JAMA Oncology adds to increasing evidence that aspirin use may help stave off colorectal cancer and suggests that aspirin is also associated with a small reduction of overall cancer risk.

Researchers looked at aspirin use among almost 136,000 men and women in two studies over 32 years. They noted that regular aspirin use—taking either a 325-mg tablet or an 81-mg tablet two or more times per week—was associated with a 3% reduction in cancers over all, although they saw no effect on major cancers like those of the breast, prostate, or lung. The researchers say the overall reduction was due mostly to a 15% risk reduction for gastrointestinal cancer and a 19% risk reduction for colorectal cancer.

News Briefs

The CDC wants doctors to stop treating chronic pain by prescribing opioids, such as oxycodone (OxyContin). The CDC published guidelines on opioid prescription March 15, 2016, in The Journal of the American Medical Association. Opioids are powerful painkillers typically used to treat severe pain after surgery or pain with terminal illness, and sometimes used to treat chronic pain. But long-term use of these drugs comes with the risk of dependence, addiction, overdose, and death, as we reported in March.

The CDC is recommending that doctors instead treat chronic pain with non-opioid painkillers, such as acetaminophen (Tylenol) or ibuprofen (Advil); anticonvulsants (gabapentin or pregabalin); tricyclic antidepressants; or serotonin-norepinephrine reuptake inhibitors. The CDC also suggests treating chronic pain with nondrug therapies, such as physical therapy. If you and your doctor feel the benefits of opioid therapy outweigh the risks, the CDC urges doctors to prescribe the lowest effective dose, and reassess risks and benefits at least every three months. The recommendation is not intended for people taking opioids for terminal illness or palliative care.

Dr. Michael Bierer explains the most common misconception about addiction and offers tips for recognizing if you might be developing an addiction.

Dr. Wynne Armand talks with Dr. Terry Schraeder about the increase in opiod addictions and shares prevention and treatment methods for those experiencing an addiction to prescription opioid medication.

Declining testosterone is a normal part of aging, but is replacement therapy right for you? Here is what you need to know.

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Testosterone replacement therapy (TRT) has surged in popularity over the past decade. Millions of older men have turned to TRT to restore hormone levels in hopes of refueling energy and reigniting their sex drive.

Yet TRT remains controversial because of its uncertain benefits and potential health risks. Safety concerns were raised years ago when studies showed a possible association between TRT and an increased risk of cardiovascular disease.

Proton-pump inhibitors are among the most-prescribed medications, but is long-term use safe?

Proton-pump inhibitors reduce stomach acid, which helps to treat symptoms of acid reflux.
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Proton-pump inhibitors (PPIs), which are used to treat a variety of gastrointestinal problems, are among the most popular drugs in the United States. In fact, the FDA estimates about one in 14 Americans has used a PPI.

Each of your medications may be affecting how the others work, leading to harmful side effects and complications.

Each additional medication you take increases the risk of drug interactions.
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Are you taking more than one drug? Are you taking a few different types of medications? Are you seeing several different doctors? If so, you may be at increased risk for drug interactions, which occur when a drug, a supplement, or even a food affects the way your body processes a medication. Such interactions can make a drug more powerful—so that a standard dose becomes an overdose—or can render it less potent or altogether ineffective.

About one in six strokes can be traced to atrial fibrillation. Doctors now have newer and better options to lessen this risk.

Close to one in 10 people ages 65 or older have atrial fibrillation (afib), the most common heart rhythm disorder. During a bout of afib, the usually rhythmic contractions of the heart's upper chambers (the atria) are replaced by an ineffectual quiver. While the symptoms, which include a racing heartbeat, dizziness, and shortness of breath, are troublesome for some people, the real threat lies in the increased risk of stroke that accompanies the condition.

When the heart takes on the afib rhythm, blood does not completely move out of the atria. Instead, it tends to pool and clot in a pouchlike extension in the upper left quadrant of the heart, called the left atrial appendage. If these clots break loose, they may travel to the brain and cause a blockage. This is known as an ischemic stroke.

It may be time to re-evaluate if it's been a while since you started using proton-pump inhibitors.

Long-term use of some heartburn medications appears to be associated with an increated risk of dementia, heart attack, and chronic kidney disease. 
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You may think you're reaching for heartburn relief when you take a proton-pump inhibitor (PPI), a type of medication that helps block the production of stomach acid. PPIs are effective, and some—such as lansoprazole (Prevacid) and omeprazole (Prilosec)—are readily available over the counter. Others, such as pantoprazole (Protonix), are frequently prescribed for long-term use. But PPIs may have risks when taken over a long period.

Even the newer, targeted cancer therapies may harm the heart.

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About 14 million people in the United States are living with cancer, a number that reflects the steady rise in cancer survivorship in recent decades. In 1980, only about half of people with cancer lived five years after diagnosis. Today, five-year cancer survival rates are greater than 70%.

Unfortunately, many cancer-suppressing treatments can have undesirable effects on the heart and blood vessels. The increasing awareness of these effects—coupled with the surge of older people being diagnosed with and surviving cancer—has spurred a new specialty known as cardio-oncology. Experts in this burgeoning field focus on promoting heart health in people with cancer, both during and after their treatment.