Mind & Mood Archive

It's not clear that supplements are effective, but some evidence is encouraging.

Some people are wary of taking antidepressants to treat their mild or moderate depression. They may not want to deal with the hassle of prescriptions, the costs, the potential side effects (such as sexual dysfunction), or the worry that medication treatment could mean an endless commitment.

Even if dementia runs in your family, smart lifestyle changes can help you improve your chances of staying ahead of it.

There are many things you can change about your life, but unfortunately, your genes are not among them. For better or worse, you are dealt a specific genetic hand when you are born. But that does not mean you are defenseless.

Take dementia, for example. If this cognitive disorder runs in your family, new research suggests there are ways to perhaps avoid the same fate.

In the journals

A new study found that a simple blood test can detect beta-amyloid protein buildup in a person's brain years before Alzheimer's disease symptoms appear. The results were published online Aug. 1, 2019, by the journal Neurology.

High amounts of beta-amyloid can clump together and form plaques on the brain, which is strongly associated with Alzheimer's disease. Other research has found that amyloid plaques can appear as early as 20 years before the first sign of Alzheimer's symptoms, such as cognitive decline and memory loss.

Research we're watching

Are men or women smarter? A recent analysis, published online July 18 by American Psychologist, shows that a majority of Americans (86%) polled in 2018 think men and women are equally intelligent. But among those who see a difference, 9% gave the edge to women, compared with only 5% who think men are smarter.

The results are a far cry from public opinion polls conducted in the 1940s, when a majority of Americans thought that men were the smarter sex, and only 36% thought that men and women were equals when it came to brains. These figures were compiled using 16 different, nationally representative, public opinion polls conducted from 1946 to 2018.

There are many medications that can be used to treat mood disorders. But finding the right one can be a lengthy process, and the choice can be more complicated than you might imagine. Just because a particular drug worked for a friend doesn't mean it will work for you. Psychiatrists and doctors who prescribe antidepressants choose a particular drug and dosage based on many factors, including the following:

• Diagnosis. Certain drugs are a better choice for specific symptoms and types of depression. For example, an antidepressant that makes you sleepy may be better when insomnia is an issue. The severity of your illness or the presence of anxiety, obsessions, or compulsions may also dictate the choice of one drug over another.
• Side effects. You may first want to choose a drug based on which side effect you most want to avoid. Medications vary in the likelihood they will cause such problems as sexual effects, weight gain, or sedation.
• Age. As you age, your body tends to break down drugs more slowly. Thus, older people may need a lower dose. For children, only a few medications have been studied carefully.
• Health. If you have certain health problems, it's best to avoid certain drugs. For example, your doctor will want to consider factors such as heart disease or neurological illnesses when recommending a drug. For this reason, it's important to discuss medical problems with a primary care doctor or psychiatrist before starting an antidepressant.
• Medications, supplements, and diet. When combined with certain drugs or substances, antidepressants may not work as well, or they may have worrisome or dangerous side effects. For example, combining an SSRI or another antidepressant with the herbal remedy St. John's wort can boost serotonin to dangerous and, in rare cases, fatal levels. Mixing St. John's wort with other drugs—including certain drugs to control HIV infection, cancer medications, and birth control pills—might lower their effectiveness. Women receiving tamoxifen for breast cancer should take an antidepressant that does not interfere with tamoxifen's effectiveness. Eating certain foods, such as aged cheeses and cured meats, while taking an MAOI can cause a dangerous rise in blood pressure.
• Alcohol or drugs. Alcohol and other substances can cause depression and make antidepressants less effective. Doctors often treat alcohol or drug addiction first if they believe either is causing the depression. In many instances, simultaneous treatment for addiction and depression is warranted.
• Personal and family mental health and medication history. If you or a member of your family has had a good response to a medication in the past, that information may guide your choice. Depending on the nature and course of your depression (for example, if your depression is long-lasting or difficult to treat), you may need a higher dose or a combination of drugs. This may also be true if an antidepressant has stopped working for you, which may occur after you've used it for some time or after you've stopped and restarted treatment with it.
• Cost. Since all antidepressants are roughly equivalent in their effectiveness, you won't lose anything by trying a generic version first.
• Your preference. Once you have learned as much as you can about the treatment options, your doctor will want to know what approach makes most sense given your lifestyle, your interests, and your judgment.

To learn more strategies for battling depression, check out Understanding Depression, a Special Health Report from Harvard Medical School. 

Research we're watching

Can emotional stress harm your bones? A new study found an association between stressful social relationships and bone problems in women. The study, which was published online July 9 by the Journal of Epidemiology & Community Health, found that women who reported high levels of social stress had lower bone density six years later. The study looked at more than 11,000 postmenopausal women. At the time of enrollment, the women filled out a questionnaire that asked them to rate their social stress levels and had their bone density measured both at enrollment and six years later at a follow-up appointment. Women who had reported high levels of stress at the initial interview showed a bigger decline in bone density at the follow-up compared with women who'd initially reported lower stress levels. This was true even after the researchers adjusted for other factors that may affect bone health, such as age, weight, smoking, alcohol use, and education, among others. The authors speculated that stress may harm bone health because stress leads to higher blood cortisol levels, a well-established reason for lower bone density. Further study is needed to understand and confirm the results.

Image: moodboard/Getty Images

Many older adults enjoy "brain games" like crosswords, chess, and computer games. But can they help improve memory?

If you are like many adults, you enjoy a good crossword, a weekly card game, or even the latest addictive phone app game. You probably even relish the mental boost they provide.

But do these types of brain games help with brain health, especially for protecting against memory loss? Well, it's complicated.

But some experts say limitations of the study raise questions about the results.

Could one of your regular pills raise your risk of dementia? A study published online June 24 by JAMA Internal Medicine found that people over age 55 who took a daily dose of certain common drugs for approximately three years had a 50% higher risk of developing dementia.

The medicines in question are in a category known as anticholinergics, which are used to treat conditions as diverse as depression, urinary incontinence, allergies, and Parkinson's disease. The study's authors say the findings should prompt doctors to use caution or potentially even avoid prescribing certain medications to people over age 45 on a long-term basis if there are other options available.

In the journals

Gingivitis (gum disease) has been linked to a higher risk of heart disease, but a recent study says that the bacteria that cause gingivitis also may be connected to Alzheimer's disease. The study was published Jan. 23, 2019, in Science Advances.

Scientists have previously found that this species of bacteria, called Porphyromonas gingivalis, can move from the mouth to the brain. Once in the brain, the bacteria release enzymes called gingipains that can destroy nerve cells, which in turn can lead to memory loss and eventually Alzheimer's.