Prostate Knowledge Archive

Most men over 50 will develop an enlarged prostate. Many different therapies are available, including medications and various types of surgery. Aquablation is gaining in popularity, and a recent study showed that improvements in urinary function from aquablation were still holding up after five years.

Roughly one in six men will be diagnosed with prostate cancer at some point in their lives, but these cancers usually aren't life-threatening. The least risky form of the disease occurs frequently with age, will not metastasize to other parts of the body, and it doesn't require any immediate treatment. So, should it even be called cancer?

Researchers are developing tools for predicting how fast prostate cancer might progress; among the most promising are those that count circulating tumor cells (CTCs) in blood samples. Research shows that high CTC counts predict poorer survival and faster disease progression. But they are also predictive for early-stage metastatic prostate cancer that still responds to hormonal therapy.

Radiation therapy for prostate cancer used to involve weeks or months of treatment. Today, radiation delivery is moving toward higher doses given with fewer sessions over shorter durations. Results from a clinical trial show that the two types of therapy offer the same long-term benefits.

Abnormal results on a prostate-specific antigen (PSA) screening test for cancer are typically followed by a systematic biopsy. But systematic biopsies can be problematic, and researchers are seeking alternatives. A large European study provides encouraging evidence favoring a different approach that uses MRI instead of biopsy.

Men with high prostate-specific antigen (PSA) levels often get a biopsy of prostate tissue to check for cancer. The results of the biopsy are calculated to create a Gleason score, which helps doctors assess whether the cancer is low-, medium-, or high-risk. Based on that information, doctors may recommend that a man follow active surveillance (in which he monitors his PSA for changes) or begin cancer treatment.

The specialized cells of our immune systems help to keep us healthy and free of infectious diseases. Immunotherapies teach those same cells to recognize and destroy cancer. Researchers are reporting promising results with a different method that involves engineered cells studded with receptors that bind to specific targets on cancer cells.

A 2024 study found that a urine test that looks for cancer genes may help identify the most serious cases of prostate cancer among men with high levels of prostate-specific antigen (PSA). This could help many men with high PSA levels avoid biopsies.

Artificial intelligence (A.I.) has made significant strides in helping doctors better diagnose and treat prostate cancer. A.I. uses mainly software programs that apply complex computational algorithms to improve precision and efficiency in diagnosis, treatment, and management. Three areas where A.I. will likely have the most impact are examining prostate biopsies with greater insight, finding hard-to-see tumors on MRI images, and determining which men undergoing radiation may also benefit from androgen deprivation therapy.

Androgen deprivation therapy can slow or control prostate cancer, and adding a second class of drugs improves survival when the disease is in advanced stages. But all drugs that block testosterone have challenging side effects, and a review of studies showed that cardiovascular risks worsen when these drugs are given together.